The University of Copenhagen participates in WP4 and WP9 of REACT through the participation of two different research teams:
The Brunak Group participates in WP4 and WP9.
The team aims for understanding multi-morbidity disease progression patterns and their relation to treatment events. The group integrates heterogeneous life science data from the molecular and clinical domains and is also engaged in methodology of translational utility, such as techniques of relevance within precision medicine. The Brunak Group has specific interest in genes and proteins, which play a role in several diseases, genes that may rationalize clinically observed patterns of multi-morbidity, or be of interest in relation to treatment strategies in the domain of chronic pathology.
The Tommerup group participates in WP9.
With more than 40 years of experience within medical and human genetics, the the Tommerup group accumulates knowledge ranging from the pre-genomic era of cytogenetics to the present genomic revolution mediated by NGS/bioinformatics. The present SARS-CoV-2 pandemic has revealed a striking excess of severe COVID-19 deaths among males, and a striking excess of females with persistent COVID symptoms. Moreover, influenza morbidity and mortality are often higher for women than men and a male predominance is seen in RSV morbidity among children. In REACT we will search for viral disease specific and shared host genetic variants that may be associated with these sex differences, with a specific focus on the X and Y chromosomes and on differentially expressed genes in males and females.