At REACT we are high-level experts in
virology, immunology, clinical medicine,
epidemiology and bioinformatics
Lower respiratory tract infections resulting from seasonal epidemics and pandemics are among the leading causes of death globally. Treatments are largely supportive showing a need for identifying novel targets for interventions and prediction models to personalize treatment. The REACT consortium unites high-level experts in virology, immunology, clinical medicine, epidemiology, and bioinformatics that through assessing genotypic, high-dimensional immunophenotypic, demographic and clinical data aim to define host-pathogen interactions of influenza, RS virus and SARS-CoV-2.
We aimed to evaluate genotypic, high-dimensional immunophenotypic, demographic, and clinical data in the context of the disease course to define host-pathogen interactions of viral respiratory tract infections, focusing on predominant viruses, i.e., influenza, respiratory syncytial virus (RSV) and severe acute respiratory virus (SARS-CoV-2), to predict the course of the disease, to allow targeting and personalisation of treatments, the identification of therapeutic targets, as well as defining and improving vaccination efforts.